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401564-36-1

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401564-36-1 Usage

Description

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester is a complex organic compound with a specific stereochemistry and functional groups. It is characterized by its 2S configuration, an oxo group at the 4-position, a 3-thiazolidinylcarbonyl group at the 2-position, and a tert-butyl ester group attached to the carboxylic acid. This molecule is a key intermediate in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester is used as an intermediate for the preparation of dipeptidyl peptidase IV (DPP-IV) inhibitors. These inhibitors play a crucial role in the treatment of type 2 diabetes by regulating glucose levels in the body. (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester's unique structure allows for the development of potent and selective DPP-IV inhibitors, which can help improve the management of diabetes and its associated complications.

Check Digit Verification of cas no

The CAS Registry Mumber 401564-36-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,1,5,6 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 401564-36:
(8*4)+(7*0)+(6*1)+(5*5)+(4*6)+(3*4)+(2*3)+(1*6)=111
111 % 10 = 1
So 401564-36-1 is a valid CAS Registry Number.

401564-36-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-((S)-1-tert-butoxycarbonyl-4-oxo-2-pyrrolidinylcarbonyl)-1,3-thiazolidine

1.2 Other means of identification

Product number -
Other names (S)-tert-butyl 3-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:401564-36-1 SDS

401564-36-1Downstream Products

401564-36-1Relevant articles and documents

Teneligliptin intermediate crystal form II and preparation method thereof

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Paragraph 0080-0084, (2021/11/26)

The invention discloses a teneligliptin intermediate. The chemical name of the teneligliptin intermediate is (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidine carboxylic acid tert-butyl ester, and the structural formula of the teneligliptin intermediate is represented by a formula I. Another purpose of the invention is to provide a crystal form II of the teneligliptin intermediate compound represented by the formula I. The X-ray powder diffraction pattern of the crystal form II has the characteristic peaks at 2[theta] value of 7.00+/-0.2 degrees, 9.20+/-0.2 degrees, 13.98+/-0.2 degrees, 16.24+/-0.2 degrees, 20.16+/-0.2 degrees, 21.02+/-0.2 degrees, 22.42+/-0.2 degrees and 30.22+/-0.2 degrees. The method has the advantages that the intermediate can be highly purified, a sample with the purity of 99.50% or above can be obtained, the method has important significance in improving the quality of the teneligliptin, and the preparation process is simple and suitable for industrial production.

Synthesis method of teneligliptin key intermediate

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, (2019/10/15)

The invention discloses a synthesis method of a teneligliptin key intermediate, and relates to the technical field of synthesis, in particular to a synthesis method of a teneligliptin key intermediate(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester. According to the synthesis method, L-hydroxyproline is subjected to an esterification reaction to obtain a compound 1; the compound 1 is protected by t-butyloxycarboryl to obtain a compound 2; the compound 2 is subjected to an oxidation reaction to obtain a compound 3; the compound 3 and thiazolidine are subjected to an ammonia ester exchange reaction to obtain a compound 4. According to the method, a synthesis route suitable for industrial production is designed aiming at the teneligliptin key intermediate,the complexity of the operation is lowered, expensive dehydration reagents are also avoided, the yield is high, the cost is low, and the synthesis method is suitable for industrial application and popularization.

Industrial production method of teneligptin intermediate

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Paragraph 0023; 0029-0034; 0040-0045; 0051-0056; 0062-0066, (2019/04/04)

The invention relates to the technical field of biochemical engineering, in particular to an industrial production method of a teneligptin intermediate (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester. The method comprises the following steps: oxidizing a raw material N-Boc-hydroxyproline through an oxidizing agent in the presence of a catalyst; performing quenching with water after reaction ends, singly treating water phase in a waste water treatment pipeline, and concentrating organic phase, so as to obtain a product N-Boc-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester crude product, and performing recrystallization on the crude product through a solvent, so as to obtain a finished product. Compared with the prior art,the industrial production method has the advantages that high-quality (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester can be efficiently and stably produced, the purity is greater than 99 percent, unknown single impurity is smaller than 0.3 percent, and three-waste treatment reach the standards.

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