N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide

Base Information

Chemical Name:N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide
CAS No.:1224969-57-6
Molecular Formula:C₁₅H₁₁F₆NOS
Molecular Weight:367.315
Hs Code.:

Synonyms:N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide

Chemical Property:

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Technology Process of N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide

There total 1 articles about N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 39234-86-1
3,5-bis(trifluoromethyl)benzenesulfonyl chloride

: 100-46-9
benzylamine

: 1224969-57-6
N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide

Guidance literature:: With triethylamine; triphenylphosphine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejic.200900521

Reference yield: 63.0%

: 1224969-57-6
N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide

: 13292-87-0
dimethyl sulfide borane

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 1224969-63-4
N-benzyl-N-diphenylphosphanyl-3,5-bis(trifluoromethyl)phenylsulfinamide borane complex

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; byproducts: H2; (N2), sulfinamide treated with dry THF, cooled to -78°C, treated with BuLi in hexanes, stirred for 15 min, treated dropwise with 1.2 equiv. of Ph2PC, stirred for 1 h, warmed to -30°C, treated with BH3*SMe2, stirred for 20 min; warmed to 0°C, treated with h2O and Et2O, aq. layer washed (Et2O), org. layer dried (MgSO4), filtered, concd.(vac.), chromy.(silica gel -hexane/EtOAc 80:20), elem. anal.;
DOI:10.1002/ejic.200900521

Reference yield:

: 1224969-57-6
N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: C₂₇H₂₀F₆NOPS

Guidance literature:: N-benzyl-3,5-bis(trifluoromethyl)phenylsulfinamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

chloro-diphenylphosphine; In tetrahydrofuran; hexane; at -78 - -30 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejic.200900521