3-Chloro-4-iodopyridine

Base Information

Chemical Name:3-Chloro-4-iodopyridine
CAS No.:77332-79-7
Molecular Formula:C5H3ClIN
Molecular Weight:239.443
Hs Code.:2933399090
European Community (EC) Number:675-067-8
DSSTox Substance ID:DTXSID50504043
Wikidata:Q72452592
Mol file:77332-79-7.mol

Synonyms:3-Chloro-4-iodopyridine;77332-79-7;MFCD00272199;Pyridine, 3-chloro-4-iodo-;3-chloro-4-iodo-pyridine;SCHEMBL1803019;3-Chloro-4-iodopyridine, 97%;DTXSID50504043;SQXBYRRNGPVSAU-UHFFFAOYSA-N;AKOS005259892;CS-W002592;PS-4667;AC-27944;SY023409;A9791;AM20061501;C2971;FT-0600238;EN300-154587;J-512237

Suppliers and Price of 3-Chloro-4-iodopyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Chloro-4-iodopyridine
5g
$ 205.00

TCI Chemical
3-Chloro-4-iodopyridine >98.0%(GC)(T)
1g
$ 132.00

SynQuest Laboratories
3-Chloro-4-iodopyridine
100 mg
$ 20.00

SynQuest Laboratories
3-Chloro-4-iodopyridine
1 g
$ 100.00

Sigma-Aldrich
3-Chloro-4-iodopyridine 97%
1g
$ 72.30

Matrix Scientific
3-Chloro-4-Iodopyridine 95+%
1g
$ 99.00

Matrix Scientific
3-Chloro-4-Iodopyridine 95+%
5g
$ 331.00

Crysdot
3-Chloro-4-Iodopyridine 97%
100g
$ 554.00

Crysdot
3-Chloro-4-Iodopyridine 97%
25g
$ 221.00

Chem-Impex
3-Chloro-4-iodopyridine,≥98%(GC) ≥98%(GC)
5G
$ 143.16

Total 68 raw suppliers

Chemical Property of 3-Chloro-4-iodopyridine

Chemical Property:

Vapor Pressure:0.046mmHg at 25°C
Melting Point:105-106 °C
Refractive Index:1.642
Boiling Point:245.001 °C at 760 mmHg
PKA:1.57±0.18(Predicted)
Flash Point:101.973 °C
PSA：12.89000
Density:2.052 g/cm³
LogP:2.33960
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Sensitive.:Light Sensitive
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:238.89987
Heavy Atom Count:8
Complexity:78.8

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-iodopyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T,Xn
Statements: 22-37/38-41
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=CC(=C1I)Cl
Uses 3-Chloro-4-iodopyridine, can be used for the preparation of difluoromethylated pyridines. It is also an intermediate for the synthesis of 5-Chloro-4-(trifluoromethyl)-2-pyridinecarboxylic Acid (C421715).

Technology Process of 3-Chloro-4-iodopyridine

There total 4 articles about 3-Chloro-4-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 626-60-8
3-Chloropyridine

: 77332-79-7
3-chloro-4-iodopyridine

Guidance literature:: 3-Chloropyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.5h;

With iodine; In tetrahydrofuran; at 20 ℃; Further stages.;
DOI:10.1002/anie.200703763

Reference yield: 3.0%

: 626-60-8
3-Chloropyridine

: 77332-79-7
3-chloro-4-iodopyridine

: 77332-90-2
3-chloro-5-iodopyridine

: 77332-89-9
2-iodo-3-pyridyl chloride

: 77332-88-8
3-chloro-4,5-diiodopyridine

Guidance literature:: With n-butyllithium; iodine; diisopropylamine; Yield given. Multistep reaction; 1.) THF, hexane, -78 grad C, 30 min, 2.) THF, hexane, -78 grad C, then slowly allowed to warm to room temperature overnight.;
DOI:10.1016/S0040-4039(00)93671-2