methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate

Base Information

• Chemical Name: methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate
• CAS No.: 1541201-68-6
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.316
• Mol file: 1541201-68-6.mol

Synonyms:methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate

Chemical Property of methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate

There total 6 articles about methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methoxy-N,N-dimethylanilne (701-56-4) + carbon dioxide (124-38-9,18923-20-1) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate (1541201-68-6)

Guidance literature:

4-methoxy-N,N-dimethylanilne; carbon dioxide; With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at -10 ℃; for 0.0833333h; Sealed tube; Glovebox;

2-(trimethylsilyl)phenyl trifluoromethanesulfonate; In tetrahydrofuran; at -30 - 100 ℃; for 24h; Sealed tube; Glovebox;

DOI:10.1021/acs.orglett.6b02845

Reference yield:

N-(4-methoxyphenyl)anthranilic acid methyl ester (21971-24-4) + methyl iodide (74-88-4) → methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate (1541201-68-6)

Guidance literature:

N-(4-methoxyphenyl)anthranilic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Cooling with ice;

methyl iodide; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1021/jo402413g

Reference yield:

N-(p-methoxyphenyl)anthranilic acid (13501-67-2) + methyl iodide (74-88-4) → methyl 2-((4-methoxyphenyl)(methyl)amino)benzoate (1541201-68-6)

Guidance literature:

N-(p-methoxyphenyl)anthranilic acid; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

DOI:10.1021/jo5011697

upstream raw materials:

N-(4-methoxyphenyl)anthranilic acid methyl ester

methyl iodide

2-bromobenzoic acid methyl ester

4-methoxy-aniline

Downstream raw materials:

N-methoxy-2-((4-methoxyphenyl)(methyl)amino)benzamide

N-methyl-N-(4-methoxyphenyl)anthranilic acid

C₁₅H₁₇NO₂

2-((4-methoxyphenyl)(methyl)amino)benzaldehyde