methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate

Base Information

Chemical Name:methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate
CAS No.:1389326-53-7
Molecular Formula:C₂₅H₃₄ClN₃O₅SSi
Molecular Weight:552.167
Hs Code.:

Synonyms:methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate

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Chemical Property of methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate

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Technology Process of methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate

There total 6 articles about methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389324-31-5
methyl 2-(4-chlorophenyl)-2-{4-[(methylsulfonyl)amino]-1H-indazol-1-yl}butanoate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1389326-53-7
methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate

Guidance literature:: methyl 2-(4-chlorophenyl)-2-{4-[(methylsulfonyl)amino]-1H-indazol-1-yl}butanoate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389326-53-7
methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: hydrogenchloride; methanol / 2 h / 20 °C

5.2: pH 9 - 10

6.1: 4-methyl-morpholine / dichloromethane / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

7.2: 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1389326-53-7
methyl 2-(4-chlorophenyl)-2-(4-(N-((2-(trimethylsilyl)ethoxy)methyl)methylsulfonamido)-1H-indazol-1-yl)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: hydrogenchloride; methanol / 2 h / 20 °C

5.2: pH 9 - 10

6.1: 4-methyl-morpholine / dichloromethane / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

7.2: 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;