9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

Base Information

Chemical Name:9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester
CAS No.:234081-76-6
Molecular Formula:C₆₁H₁₀₈N₄O₈
Molecular Weight:1025.55
Hs Code.:

Synonyms:9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

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Chemical Property of 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

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Technology Process of 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

There total 7 articles about 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 234081-96-0
10-(tert-butoxy)-10-oxodecanoic acid

: 234081-53-9
(S)-2-Amino-N-((S)-1,2-bis-hexadecylcarbamoyl-ethyl)-succinamic acid benzyl ester

: 234081-76-6
9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

Guidance literature:: With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; In chloroform; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

: 143-27-1
hexadecylamine

: 234081-76-6
9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 3 h / 20 °C

2: 78 percent / trifluoroacetic acid / CHCl₃ / 2 h / 20 °C

3: 46 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂; dimethylformamide / 5 h / 20 °C

4: 81 percent / trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

5: 51 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

: 229467-49-6
2-amino-N¹,N⁴-dihexadecyl-succinamide

: 234081-76-6
9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂; dimethylformamide / 5 h / 20 °C

2: 81 percent / trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

3: 51 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(02)00053-1