9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid

Base Information

• Chemical Name: 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid
• CAS No.: 234081-86-8
• Molecular Formula: C₅₇H₁₀₀N₄O₈
• Molecular Weight: 969.443
• Mol file: 234081-86-8.mol

Synonyms:9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid

Chemical Property of 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid

There total 9 articles about 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester (234081-76-6) → 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid (234081-86-8)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃;

DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

hexadecylamine (143-27-1) → 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid (234081-86-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 3 h / 20 °C

2: 78 percent / trifluoroacetic acid / CHCl₃ / 2 h / 20 °C

3: 46 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂; dimethylformamide / 5 h / 20 °C

4: 81 percent / trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

5: 51 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 20 °C

6: 99 percent / trifluoroacetic acid / CHCl₃ / 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

10-(tert-butoxy)-10-oxodecanoic acid (234081-96-0) → 9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid (234081-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 20 °C

2: 99 percent / trifluoroacetic acid / CHCl₃ / 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0009-3084(02)00053-1

upstream raw materials:

9-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-nonanoic acid tert-butyl ester

1,10-decanedioic acid

hexadecylamine

10-(tert-butoxy)-10-oxodecanoic acid