2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate

Base Information

Chemical Name:2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate
CAS No.:1572383-53-9
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate

Chemical Property:

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Technology Process of 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate

There total 6 articles about 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1572383-01-7
2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenol

: 123-62-6
propionic acid anhydride

: 1572383-53-9
2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol500328t

Reference yield:

: 95-55-6
2-amino-phenol

: 1572383-53-9
2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid / 2,2,2-trifluoroethanol / 1 h / 55 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1021/ol500328t

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 1572383-53-9
2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid / 2,2,2-trifluoroethanol / 1 h / 55 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1021/ol500328t