Technology Process of biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone
There total 5 articles about biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
magnesium sulfate; potassium carbonate;
In
1,4-dioxane;
at 70 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium alcoholate / ethanol / 2 h / Reflux
2: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C
3: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C
4: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C
5: magnesium sulfate; potassium carbonate / 1,4-dioxane / 70 °C
With
formic acid; sodium hydrogencarbonate; magnesium sulfate; potassium carbonate; triethylamine; trichlorophosphate;
palladium(II) hydroxide; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C
2: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C
3: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C
4: magnesium sulfate; potassium carbonate / 1,4-dioxane / 70 °C
With
formic acid; sodium hydrogencarbonate; magnesium sulfate; potassium carbonate; triethylamine; trichlorophosphate;
palladium(II) hydroxide; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;