biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

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Chemical Name:biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone
CAS No.:1332454-29-1
Molecular Formula:C₂₆H₂₈N₄O₂
Molecular Weight:428.534
Hs Code.:

Synonyms:biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

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Chemical Property of biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

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Technology Process of biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

There total 5 articles about biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4045-24-3
4-methoxypiperidine

: 1332455-32-9
biphenyl-4-yl-(4-chloro-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

: 1332454-29-1
biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

Guidance literature:: With magnesium sulfate; potassium carbonate; In 1,4-dioxane; at 70 ℃;

Reference yield:

: 1454-53-1
ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

: 1332454-29-1
biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium alcoholate / ethanol / 2 h / Reflux

2: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C

3: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

4: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

5: magnesium sulfate; potassium carbonate / 1,4-dioxane / 70 °C

With formic acid; sodium hydrogencarbonate; magnesium sulfate; potassium carbonate; triethylamine; trichlorophosphate; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetonitrile;

Reference yield:

: 109229-22-3
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

: 1332454-29-1
biphenyl-4-yl-[4-(4-methoxypiperidin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C

2: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

3: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

4: magnesium sulfate; potassium carbonate / 1,4-dioxane / 70 °C

With formic acid; sodium hydrogencarbonate; magnesium sulfate; potassium carbonate; triethylamine; trichlorophosphate; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;