(E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide

Base Information

Chemical Name:(E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide
CAS No.:1389325-42-1
Molecular Formula:C₂₁H₂₀ClN₃O₂S
Molecular Weight:413.928
Hs Code.:

Synonyms:(E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide

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Chemical Property of (E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide

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Technology Process of (E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide

There total 10 articles about (E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389326-62-8
(E)-4-(4-amino-1H-indol-1-yl)-4-(4-chlorophenyl)hex-2-enenitrile

: 124-63-0
methanesulfonyl chloride

: 1389325-42-1
(E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 20 ℃;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389325-42-1
(E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

4.2: 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C

7.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C

8.1: hydrogenchloride / methanol / 2 h / 20 °C

9.1: 4-methyl-morpholine / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 4769-97-5
4-nitro-1H-indoIe

: 1389325-42-1
(E)-N-(1-(3-(4-chlorophenyl)-1-cyanopent-1-en-3-yl)-1H-indol-4-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen / 10% Pt/activated carbon / ethyl acetate / 3 h / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane; water

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

4.2: 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C

7.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C

8.1: hydrogenchloride / methanol / 2 h / 20 °C

9.1: 4-methyl-morpholine / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;