(1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

Base Information

Chemical Name:(1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid
CAS No.:129245-49-4
Molecular Formula:C₃₅H₅₆O₉
Molecular Weight:620.824
Hs Code.:

(1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

Synonyms:(1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

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Chemical Property of (1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

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Technology Process of (1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

There total 20 articles about (1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 129245-48-3
Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,4S,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohexan-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie...

: 129245-49-4
(1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 10h; Ambient temperature;
DOI:10.1039/a605894i

Reference yield:

: 129245-41-6
(1R,2S,4S,5S)-2-Hydroxy-4-methoxy-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylic acid

: 129245-49-4
(1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / DMAP, DCC / CH₂Cl₂ / 16 h / Ambient temperature

2: 91 percent / O₂, tetraphenylporphyrin / CH₂Cl₂; methanol / 0.33 h / -78 °C / Irradiation

3: 1.) t-BuLi, 2.) lithium hexamethyldisilazide / 1.) THF, -40 deg C, 0.5 h, 2.) THF, -78 deg C to -15 deg C, 3 h

4: 2.) I₂ / 1.) ether, 2.) C₆H₆, 8 h, sunlight

5: 100 percent / TBAF / tetrahydrofuran / 10 h / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; oxygen; 5,15,10,20-tetraphenylporphyrin; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/a605894i

Reference yield:

: 129245-40-5
Ethyl (1R,2S,4S,5S)-2-hydroxy-4-methoxy-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate

: 129245-49-4
(1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / aq. NaOH / ethanol / 48 h / 5 °C

2: 82 percent / DMAP, DCC / CH₂Cl₂ / 16 h / Ambient temperature

3: 91 percent / O₂, tetraphenylporphyrin / CH₂Cl₂; methanol / 0.33 h / -78 °C / Irradiation

4: 1.) t-BuLi, 2.) lithium hexamethyldisilazide / 1.) THF, -40 deg C, 0.5 h, 2.) THF, -78 deg C to -15 deg C, 3 h

5: 2.) I₂ / 1.) ether, 2.) C₆H₆, 8 h, sunlight

6: 100 percent / TBAF / tetrahydrofuran / 10 h / Ambient temperature

With dmap; sodium hydroxide; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; oxygen; 5,15,10,20-tetraphenylporphyrin; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1039/a605894i