di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate

Base Information

• Chemical Name: di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate
• CAS No.: 1037834-32-4
• Molecular Formula: C₁₉H₂₇NO₆
• Molecular Weight: 365.426
• Mol file: 1037834-32-4.mol

Synonyms:di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate

Chemical Property of di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate

There total 3 articles about di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyl [5-(methoxycarbonyl)-2-nitrophenyl]malonate (196103-67-0) → di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate (1037834-32-4)

Guidance literature:

nickel; In methanol;

Reference yield:

methyl 3-fluoro-4-nitrobenzoate (185629-31-6) → di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate (1037834-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: nickel / methanol

With sodium hydride; nickel; In methanol; N,N-dimethyl-formamide;

Reference yield:

3-fluoro-4-nitrobenzoic acid (403-21-4) → di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate (1037834-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 5.5 h / Heating / reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 0 - 20 °C

3.1: nickel / methanol

With sulfuric acid; sodium hydride; nickel; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

di-tert-butyl [5-(methoxycarbonyl)-2-nitrophenyl]malonate

methyl 3-fluoro-4-nitrobenzoate

3-fluoro-4-nitrobenzoic acid

Downstream raw materials:

di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-5-(methoxycarbonyl)phenyl]malonate

methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-2-oxoindoline-5-carboxylic acid

benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

Refernces