methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

Base Information

Chemical Name:methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate
CAS No.:1037834-34-6
Molecular Formula:C₂₃H₂₄N₂O₅
Molecular Weight:408.454
Hs Code.:

Synonyms:methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

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Chemical Property of methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

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Technology Process of methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

There total 7 articles about methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1037834-45-9
benzyl 4-(2-chloro-N-(4-(methoxycarbonyl)phenyl)acetamido)-piperidine-1-carboxylate

: 1037834-34-6
methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

Guidance literature:: With palladium diacetate; triethylamine; johnphos; In 2-methyltetrahydrofuran; isopropyl alcohol; at 70 - 75 ℃; for 2h; Inert atmosphere;
DOI:10.15227/orgsyn.090.0074

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1037834-34-6
methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium triacetoxy borohydride; acetic acid / 1,2-dichloro-ethane / Large scale reaction

2.1: pyridine / ethyl acetate / 0.67 h / 15 - 25 °C / Large scale reaction

3.1: palladium diacetate; johnphos / 2-methyltetrahydrofuran; isopropyl alcohol / 0.5 h / Inert atmosphere; Large scale reaction

3.2: 2.5 h / 71 °C / Large scale reaction

With pyridine; sodium triacetoxy borohydride; palladium diacetate; acetic acid; johnphos; In 2-methyltetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/op200332p

Reference yield:

: 196103-67-0
di-tert-butyl [5-(methoxycarbonyl)-2-nitrophenyl]malonate

: 1037834-34-6
methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: nickel / methanol

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 76 h / 20 °C

3: toluene-4-sulfonic acid / toluene / 2 h / Heating / reflux

With sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; acetic acid; nickel; In methanol; 1,2-dichloro-ethane; toluene;