3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane

Base Information

Chemical Name:3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane
CAS No.:183004-95-7
Molecular Formula:C₂₆H₃₆N₄O₅S₂
Molecular Weight:548.728
Hs Code.:

Synonyms:3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane

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Chemical Property of 3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane

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Technology Process of 3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane

There total 7 articles about 3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 333-20-0
potassium thioacyanate

: 183004-94-6
3-S-(N-tert-butyloxyformamido)-[2R-hydroxy-1-[(4-aminophenylsulfonyl)(2-methylpropyl)]amino]-4-phenylbutane

: 183004-95-7
3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane

Guidance literature:: potassium thioacyanate; 3-S-(N-tert-butyloxyformamido)-[2R-hydroxy-1-[(4-aminophenylsulfonyl)(2-methylpropyl)]amino]-4-phenylbutane; With copper(II) sulfate; In methanol; for 2h; Heating / reflux;

In methanol; water; Heating / reflux;

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile; With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 183004-94-6
3-S-(N-tert-butyloxyformamido)-[2R-hydroxy-1-[(4-aminophenylsulfonyl)(2-methylpropyl)]amino]-4-phenylbutane

: 183004-95-7
3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / CuSO₄ / methanol / 2 h / Heating

2: 75 percent / Et₃N / tetrahydrofuran / 18 h / 20 °C

With copper(II) sulfate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2003.07.001

Reference yield:

: 143224-62-8
(2R,3S)-3-benzyloxycarbonylamino-2-hydroxy-1-(N-isobutylamino)-4-phenylbutane

: 183004-95-7
3-S-(N-t-butyloxyformamido)-2R-hydroxy-1-[(2-aminobenzothiazol-6-sulfonyl)(2-methylpropyl)amino]-4-phenylbutane

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 70 percent / H₂ / Pd/C / ethyl acetate

3: 94 percent / Et₃N / tetrahydrofuran / 16 h

4: 93 percent / CuSO₄ / methanol / 2 h / Heating

5: 75 percent / Et₃N / tetrahydrofuran / 18 h / 20 °C

With hydrogen; copper(II) sulfate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.07.001