(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate

Base Information

• Chemical Name: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate
• CAS No.: 1542432-73-4
• Molecular Formula: C₁₆H₂₅F₆O₅P
• Molecular Weight: 442.336
• Mol file: 1542432-73-4.mol

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate

Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate

There total 4 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoroethanol (75-89-8) + C12H21Cl2O3P → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate (1542432-73-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In benzene; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.11.005

Reference yield:

(diethoxy-phosphoryl)-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (141540-20-7) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate (1542432-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentachloride / 14.08 h / 0 - 75 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / benzene / 4 h / 0 - 20 °C / Inert atmosphere

With phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; In benzene;

DOI:10.1016/j.tetasy.2013.11.005

Reference yield:

(1R,2S,5R)-menthol bromoacetate (16832-20-5,32815-12-6,55284-67-8) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate (1542432-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 3 h / 100 °C / Inert atmosphere

2: phosphorus pentachloride / 14.08 h / 0 - 75 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / benzene / 4 h / 0 - 20 °C / Inert atmosphere

With phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; In benzene; 1: |Arbuzov Reaction;

DOI:10.1016/j.tetasy.2013.11.005

upstream raw materials:

(diethoxy-phosphoryl)-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

2,2,2-trifluoroethanol

(1R,2S,5R)-menthol bromoacetate

(-)-menthol

Downstream raw materials:

(2E,4E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]-5-phenylpenta-2,4-dienoate