2,5-Piperidinedione

Base Information

• Chemical Name: 2,5-Piperidinedione
• CAS No.: 52065-78-8
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.116
• Hs Code.: 2933399990
• Mol file: 52065-78-8.mol

Synonyms:2,5-Piperidinedione

Chemical Property of 2,5-Piperidinedione

Chemical Property:

• Vapor Pressure: 1.98E-05mmHg at 25°C
• Refractive Index: 1.47
• Boiling Point: 362.1 °C at 760 mmHg
• PKA: 14.12±0.20(Predicted)
• Flash Point: 193.6 °C
• Density: 1.184 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Piperidine-2,5-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Piperidine-2,5-dione is used in preparation of piperidine-dione from aminoglutaric acid via lactonization, reduction, azidation, reductive ring expansion and Dess-Martin Periodinane oxidation.

Technology Process of 2,5-Piperidinedione

There total 13 articles about 2,5-Piperidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,5-dihydroxypyridine (5154-01-8,24154-26-5) → (RS)-5-hydroxypiperidin-2-one (19365-07-2) + piperidine-2,5-dione (52065-78-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 30 ℃; for 5h;

DOI:10.1002/ardp.19843170405

Reference yield: 68.0%

5-benzyloxy-N-benzylpyridine-2-one (90292-53-8) → piperidine-2,5-dione (52065-78-8) + 1-benzyl-2,5-piperidinedione (90292-54-9) + 1-benzyl-5-hydroxypiperidin-2-one (87179-80-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 30 ℃; for 3h;

DOI:10.1002/ardp.19843170405

Reference yield: 65.0%

5,5-dimethoxy-2-piperidone → piperidine-2,5-dione (52065-78-8)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 8h;

upstream raw materials:

2,5-dihydroxypyridine

5-benzyloxy-N-benzylpyridine-2-one

2-Pyridone

ALA

Downstream raw materials:

(RS)-5-hydroxypiperidin-2-one

5-aminolevulinic acid hydrochloride

1-benzyl-5-(benzyloxy)piperidin-2-one

1-benzyl-5-hydroxypiperidin-2-one

Refernces

• 1、 -. "Preparation method of pipyridine-2,5-dione and Pharmaceutical composition comprising the same". . . Retrieved 2017/01/17.
• 2、 Herdeis, Claus,Dimmerling, Anna. "A Three-Step Synthesis of δ-Aminolaevulinic Acid". . p. 304 - 306. Retrieved 2007/10/02.