19365-07-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-5-Hydroxy-piperidin-2-one is used as a key intermediate in the synthesis of various pharmaceuticals, leveraging its unique structure and reactivity to contribute to the development of new medications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (R)-5-Hydroxy-piperidin-2-one is utilized as a chiral building block, which is essential for the creation of enantiomerically pure compounds. This is vital for ensuring the desired biological activity and minimizing potential side effects in drug development.
Used in Neurotransmitter and Amino Acid Biosynthesis:
(R)-5-HYDROXY-PIPERIDIN-2-ONE is used as a precursor in the biosynthesis of the neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid proline, playing a significant role in metabolic pathways and contributing to the regulation of key physiological processes.
Used in Drug Development:
(R)-5-Hydroxy-piperidin-2-one has potential applications in the development of new drugs, particularly in the areas of central nervous system modulation and other therapeutic areas where GABAergic or proline-related pathways are implicated. Its role in these pathways makes it a promising candidate for the treatment of various disorders.

Upstream product

• 19365-05-0 1,5-Dihydroxy-1H-2-pyridon 
• 52065-78-8 piperidine-2,5-dione 
• 5154-01-8 2,5-dihydroxypyridine 
• 142-08-5 2-Pyridone 
• 617-65-2 Glutamic acid 
• 4344-84-7 5-oxo-tetrahydro-furan-2-carboxylic acid 
• 10374-51-3 5-hydroxymethyl-4,5-dihydrofuranone 
• 179532-81-1 5-(azidomethyl)dihydrofuran-2(3H)-one 
• 57859-04-8 (5-oxotetrahydrofuran-2-yl)methyl formate 
• 591-80-0 pent-4-enoic acid 
• 132210-73-2 N-(iodoacetyl)allylamine 
• 1179999-39-3 methyl 4-hydroxy-5-nitropentanoate 

Downstream Products

• 87179-79-1 1-benzyl-5-(benzyloxy)piperidin-2-one 
• 87179-80-4 1-benzyl-5-hydroxypiperidin-2-one 
• 97899-35-9 2-piperidon-5-yl p-toluenesulfonate 
• 1416946-24-1 6-oxopiperidin-3-yl((S)-(3-fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamate 
• 62414-68-0 (3R)-piperidin-3-ol 
• 24211-55-0 (S)-3-hydroxypiperidine 
• 143900-43-0 tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate 
• 52065-78-8 piperidine-2,5-dione 
• 124032-31-1 benzyl 6-hydroxy-4-azaspiro[2,5]octane-4-carboxylate 

Relevant academic research and scientific papers

A Three-Step Synthesis of δ-Aminolaevulinic Acid

Piperidine-2,5-dione (4) is prepared by catalytic hydrogenation of 5-hydroxy-2-pyridone (3).Ring opening of the lactam 4 with concentrated hydrochloric acid yields the hydrochloride of δ-aminolaevulinic acid (2).

CRYSTAL FORM I OF A 5-AMINOPYRAZOLE CARBOXAMIDE COMPOUND AS BTK INHIBITOR

Disclosed is a new crystal form of a 5-aminopyrazole carboxamide compound as shown in Formula (I). Also disclosed are a preparation method for said crystal form of said compound, a pharmaceutical composition of said crystal form of said compound, and uses thereof.

N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection: (I) wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.

5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF

The present application discloses novel 5-aminopyrazole carboxamide compounds as shown in formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof. In addition, the present application further discloses a method for the preparation of the compounds, a pharmaceutical composition comprising a compound of the invention and the use of the compounds.

Preparation method of 2,5-piperidione

The invention relates to a preparation method of 2,5-piperidione. 2-glutamic acid is used as a starting raw material to perform closed loop reaction to produce a compound 2 under the effects of NaNO2; a compound 3 is produced through borane reduction; a compound 4 is produced under the effects of methylsufonyl chloride; a compound 5 is produced through substitution under the sodium azide effect; a compound 6 is produced through Pd/H2 under the reduction effect; a target compound is generated under the effect of Dess-Martin periodinane. The preparation method has the advantages that the raw materials are cheap and can be easily obtained; the synthetic method is simple; the method belongs to a fire-new method for synthesizing 2,5-piperidione. The method meets the requirements of large-scale industrial production.

TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS

Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have the above structure, where the definitions of the variables are provided herein.

Deoligomerization: a new route to lactams from unsaturated amides via radical oligomerization.

[reaction: see text] Triethylborane-initiated atom transfer radical oligomerization of N-allyl or N-(3-butenyl)iodoacetamides followed by treatment with hydrochloric acid and subsequent neutralization with K(2)CO(3) led to the formation of the corresponding 5-hydroxyl-substituted delta-lactams or caprolactams, respectively. This oligomerization-deoligomerization sequence serves as an alternative to the corresponding intramolecular cyclization reactions.