87179-80-4

Usage

Piperidinone derivative

1-benzyl-5-hydroxypiperidin-2-one is a derivative of piperidinone, which is a heterocyclic organic compound with a six-membered ring structure.

Benzyl group attached to nitrogen

The compound has a benzyl group (a phenyl group connected to a methyl group) attached to the nitrogen atom of the piperidinone ring.

Hydroxyl group at the 5-position

The compound has a hydroxyl group (-OH) attached to the 5-position of the piperidinone ring, which refers to the position of the hydroxyl group on the ring.

Pharmacological applications

1-benzyl-5-hydroxypiperidin-2-one has been studied for its potential pharmacological applications, including as a precursor for the synthesis of various pharmaceuticals.

Dopamine D1 receptor antagonist

The compound has been investigated for its potential as a dopamine D1 receptor antagonist, which means it may be able to block or reduce the activity of dopamine D1 receptors in the brain.

Treatment of addiction and neurological disorders

1-benzyl-5-hydroxypiperidin-2-one has been studied as a potential drug for the treatment of addiction and neurological disorders due to its potential dopamine D1 receptor antagonist activity.

Synthesis of pharmaceutical intermediates and organic compounds

The compound has been used in the synthesis of pharmaceutical intermediates and organic compounds due to its unique structure and reactivity.

Upstream product

• 591-80-0 pent-4-enoic acid 
• 100-46-9 benzylamine 
• 1351987-79-5 3-(1-benzylaziridin-2-yl)propionamide 
• 952024-06-5 1-benzyl-2-(2-cyanoethyl)-aziridine 
• 142-08-5 2-Pyridone 
• 52065-78-8 piperidine-2,5-dione 
• 19365-07-2 (RS)-5-hydroxypiperidin-2-one 
• 87179-79-1 1-benzyl-5-(benzyloxy)piperidin-2-one 
• 90292-53-8 5-benzyloxy-N-benzylpyridine-2-one 
• 625437-73-2 (S)-N-benzyl-5-oxotetrahydrofuran-2-carboxamide 
• 87179-81-5 (-)-(5S)-5-(tert-butyldimethylsilanyloxy)piperidin-2-one 
• 24211-54-9 (S)-5-hydroxypiperidin-2-one 
• 87179-79-1 (S)-1-benzyl-5-(benzyloxy)piperidin-2-one 
• 5154-01-8 2,5-dihydroxypyridine 

Downstream Products

• 913566-53-7 (3aS,7aS)-4-benzyltetrahydrofuro[3,2-b]pyridine-2,5(3H,6H)-dione 
• 913566-66-2 (3aS,7aS)-4-benzyl-2-hydroxyhexahydrofuro[3,2-b]pyridin-5(6H)-one 
• 913566-58-2 (R)-1-benzyl-5-(α-diazoacetoxy)piperidin-2-one 
• 87179-79-1 (S)-1-benzyl-5-(benzyloxy)piperidin-2-one 
• 913566-57-1 (R)-1-benzyl-5-hydroxypiperidin-2-one 
• 913566-52-6 (S)-1-benzyl-5-(α-diazoacetoxy)piperidin-2-one 
• 134746-54-6 (S)-1-Benzyl-5-(tert-butyl-diphenyl-silanyloxy)-piperidin-2-one 
• 134746-55-7 1-Benzyl-5S-t-butyldiphenylsiloxy-3RS-phenylselenyl-2-piperidon 
• 134746-56-8 1-Benzyl-5S-t-butyldiphenylsiloxy-3,4-dehydro-2-piperidon 

Relevant academic research and scientific papers

Oxyamination of Unactivated Alkenes with Electron-Rich Amines and Acids via a Catalytic Triiodide Intermediate

An aerobic catalytic oxidation process is described for the olefin oxyamination using acids and primary amines as the sources of O and N. Our mechanistic findings point to the formation of triiodide as a critical catalytic intermediate to account for the

Mild Metal-Free Hydrosilylation of Secondary Amides to Amines

The combination of amide activation by Tf2O with B(C6F5)3-catalyzed hydrosilylation with TMDS constitutes a method for the one-pot reduction of secondary amides to amines under mild conditions. The method displays a broad applicability for the reduction of many types of substrates, and shows good compatibility and excellent chemoselectivity for many sensitive functional groups. Reductions of a multifunctionalized α,β-unsaturated amide obtained from another synthetic methodology, and a C-H functionalization product produced the corresponding amines in good to excellent yield. Chemoselective reduction of enantiomeric pure (ee >99%) tetrahydro-5-oxo-2-furaneamides yielded 5-(aminomethyl)dihydrofuran-2(3H)-ones in a racemization-free manner. The latter were converted in one pot to N-protected 5-hydroxypiperidin-2-ones, which are building blocks for the synthesis of many natural products. Further elaboration of an intermediate led to a concise four-step synthesis of -epi-pseudoconhydrine.

Chemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactones

Treatment of 1-arylmethyl-2-(2-cyanoethyl)aziridines with a nitrile hydratase afforded the corresponding 2-(2-carbamoylethyl)aziridines, which underwent rearrangement into 5-hydroxypiperidin-2-ones upon heating under microwave irradiation. In addition, tr

Nonracemic bicyclic lactam lactones via regio- and cis-diastereocontrolled C-H insertion. Asymmetric synthesis of (8S,8aS)-octahydroindolizidin-8-ol and (1S,8aS)-octahydroindolizidin-1-ol

(Chemical Equation Presented) The Rh2(MPPIM)4- catalyzed intramolecular C-H insertion reaction of (S)- and (R)-1-benzyl-5-(R- diazoacetoxy)piperidin-2-one and (S)-1-benzyl-4-(α-diazoacetoxy) pyrrolidin-2-one proceeds with high regios

Regio- and diastereocontrolled C-H insertion of chiral γ- and δ-lactam diazoacetates. Application to the asymmetric synthesis of (8S,8aS)-8-hydroxyindolizidine

γ- and δ-Lactam diazoacetates undergo efficient intramolecular C-H insertion catalyzed by Rh2(MPPIM)4 with excellent regioselectivity and cis-diastereoselectivity to provide synthetically useful bicyclic lactam lactones. The Royal So

A Three-Step Synthesis of δ-Aminolaevulinic Acid

Piperidine-2,5-dione (4) is prepared by catalytic hydrogenation of 5-hydroxy-2-pyridone (3).Ring opening of the lactam 4 with concentrated hydrochloric acid yields the hydrochloride of δ-aminolaevulinic acid (2).