methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

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Chemical Name:methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate
CAS No.:1418718-50-9
Molecular Formula:C₂₇H₂₄F₂N₂O₄
Molecular Weight:478.495
Hs Code.:

Synonyms:methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

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Chemical Property of methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

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Technology Process of methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

There total 14 articles about methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1418718-53-2
C₂₉H₂₉F₂N₃O₂Si

: 1418718-50-9
methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: With sulfuric acid; at 0 - 85 ℃; under 760.051 Torr;

Reference yield:

: 1418718-41-8
methyl 4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

: 1418718-50-9
methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / 760.05 Torr / Cooling with ice

2: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

3: zinc(II) iodide / dichloromethane / 0.67 h / 760.05 Torr / Cooling with ice

4: sulfuric acid / 0 - 85 °C / 760.05 Torr

With lithium aluminium tetrahydride; sulfuric acid; pyridinium chlorochromate; zinc(II) iodide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1418718-47-4
4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

: 1418718-50-9
methyl 2-(4-(chroman-6-yl)-1-(3,4-difluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) iodide / dichloromethane / 0.67 h / 760.05 Torr / Cooling with ice

2: sulfuric acid / 0 - 85 °C / 760.05 Torr

With sulfuric acid; zinc(II) iodide; In dichloromethane;