tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

Base Information

Chemical Name:tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate
CAS No.:1354819-07-0
Molecular Formula:C₂₅H₁₈ClF₅N₄O₅S₂
Molecular Weight:649.019
Hs Code.:

Synonyms:tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

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Chemical Property of tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

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Technology Process of tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

There total 4 articles about tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354819-15-0
4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenol

: 1235406-85-5
tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

: 1354819-07-0
tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

Guidance literature:: 4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenol; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.0833333h;

tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 61721-07-1
4-fluoro-3-(trifluoromethyl)phenol

: 1354819-07-0
tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; acetic acid; N-iodo-succinimide / 3 h / 0 - 20 °C

2.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 45 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

3.2: 18 h / 20 °C

With N-iodo-succinimide; copper(l) iodide; sulfuric acid; acetic acid; cesium fluoride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1354819-14-9
4-fluoro-2-iod-5-(trifluoromethyl)phenol

: 1354819-07-0
tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 45 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h

2.2: 18 h / 20 °C

With copper(l) iodide; cesium fluoride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;