Technology Process of 3-isopropoxy-4-vinylbenzoic acid
There total 3 articles about 3-isopropoxy-4-vinylbenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 90 percent / Cs2CO3 / acetone / 10 h / Heating
2.1: aq. H2SO4; NaNO2 / methanol / 0.25 h / 0 °C
2.2: 86 percent / KI; Cu / methanol / 8 h / Heating
3.1: 95 percent / Pd(PPh3)4 / toluene / 12 h / Heating
4.1: aq. NaOH / methanol / 20 °C
With
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); sulfuric acid; caesium carbonate; sodium nitrite;
In
methanol; acetone; toluene;
2.2: Sandmeyer reaction / 3.1: Stille coupling;
DOI:10.1021/ja0446404
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / Pd(PPh3)4 / toluene / 12 h / Heating
2: aq. NaOH / methanol / 20 °C
With
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0);
In
methanol; toluene;
1: Stille coupling;
DOI:10.1021/ja0446404
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: aq. H2SO4; NaNO2 / methanol / 0.25 h / 0 °C
1.2: 86 percent / KI; Cu / methanol / 8 h / Heating
2.1: 95 percent / Pd(PPh3)4 / toluene / 12 h / Heating
3.1: aq. NaOH / methanol / 20 °C
With
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); sulfuric acid; sodium nitrite;
In
methanol; toluene;
1.2: Sandmeyer reaction / 2.1: Stille coupling;
DOI:10.1021/ja0446404
