sulfide

Base Information

• Chemical Name: sulfide
• CAS No.: 213380-63-3
• Molecular Formula: C₁₆H₁₄O₂S
• Molecular Weight: 270.352
• Mol file: 213380-63-3.mol

Synonyms:sulfide

Chemical Property of sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sulfide

There total 5 articles about sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-phenyldihydrofuran-2-one (6836-98-2) + diphenyldisulfane (882-33-7) → sulfide (213380-63-3)

Guidance literature:

3-phenyldihydrofuran-2-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; then warming to -20 deg C over 1 h;

diphenyldisulfane; In tetrahydrofuran; at -78 ℃; then warming to -20 deg C over 1.5 h and exposure at this temperature for 0.5 h;

DOI:10.1080/00397919808004439

Reference yield:

benzaldehyde (100-52-7) → sulfide (213380-63-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 100 percent / piperidine; benzoic acid / benzene / refluxing overnight under an argon atmosphere with Dean-Stark trap

2.1: 77 percent / ethanol; H₂O / 70 °C / stirring overnight at 70 deg C

4.1: 79 percent / sulfuric acid / aq. ethanol / 24 h / reflux

5.1: n.BuLi; diisopropylamine; HMPTA / tetrahydrofuran; hexane / 0.25 h / -78 °C / then warming to -20 deg C over 1 h

5.2: 62 percent / tetrahydrofuran / -78 °C / then warming to -20 deg C over 1.5 h and exposure at this temperature for 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sulfuric acid; diisopropylamine; piperidine; benzoic acid; In tetrahydrofuran; ethanol; hexane; water; benzene; 1.1: Condensation / 2.1: Cyanidation / 3.1: Reduction / 4.1: Cyclization / 5.1: Metallation / 5.2: Substitution;

DOI:10.1080/00397919808004439

Reference yield:

3-cyano-3-phenylpropanoic acid ethyl ester (14025-83-3) → sulfide (213380-63-3)

Guidance literature:

Multi-step reaction with 3 steps

2.1: 79 percent / sulfuric acid / aq. ethanol / 24 h / reflux

3.1: n.BuLi; diisopropylamine; HMPTA / tetrahydrofuran; hexane / 0.25 h / -78 °C / then warming to -20 deg C over 1 h

3.2: 62 percent / tetrahydrofuran / -78 °C / then warming to -20 deg C over 1.5 h and exposure at this temperature for 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sulfuric acid; diisopropylamine; In tetrahydrofuran; ethanol; hexane; 1.1: Reduction / 2.1: Cyclization / 3.1: Metallation / 3.2: Substitution;

DOI:10.1080/00397919808004439

upstream raw materials:

3-phenyldihydrofuran-2-one

diphenyldisulfane

3-cyano-3-phenylpropanoic acid ethyl ester

4-hydroxy-2-phenyl-butanenitrile

Downstream raw materials:

3-phenyl-2(5H)-furanone