2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid

Base Information

• Chemical Name: 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid
• CAS No.: 1335025-26-7
• Molecular Formula: C₂₅H₂₈ClN₃O₃
• Molecular Weight: 453.969
• Mol file: 1335025-26-7.mol

Synonyms:2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid

Chemical Property of 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid

There total 2 articles about 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

mono-N-acetylhexamethylenediamine (49631-88-1) + 6-chloro-2-chloromethyl-4-phenylquinoline-3-carboxylic acid ethyl ester (126334-85-8) → 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid (1335025-26-7)

Guidance literature:

mono-N-acetylhexamethylenediamine; 6-chloro-2-chloromethyl-4-phenylquinoline-3-carboxylic acid ethyl ester; With potassium carbonate; for 0.125h; Microwave irradiation;

With hydrogenchloride; In dichloromethane; water;

DOI:10.1016/j.ejmech.2011.05.035

Reference yield:

5-chloro-2-aminobenzophenone (719-59-5) → 2-[6-(acetamido)hexylaminomethyl]-6-chloro-4-phenylquinoline-3-carboxylic acid (1335025-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / Microwave irradiation

2: potassium carbonate / 0.12 h / Microwave irradiation

With hydrogenchloride; potassium carbonate; In water; 1: Friedlaender synthesis;

DOI:10.1016/j.ejmech.2011.05.035

upstream raw materials:

mono-N-acetylhexamethylenediamine

6-chloro-2-chloromethyl-4-phenylquinoline-3-carboxylic acid ethyl ester

5-chloro-2-aminobenzophenone