5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide

Base Information

Chemical Name:5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide
CAS No.:551002-09-6
Molecular Formula:C₁₇H₁₅NO₅
Molecular Weight:313.31
Hs Code.:

Synonyms:5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide

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Chemical Property of 5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide

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Technology Process of 5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide

There total 6 articles about 5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 551001-41-3
5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid

: 551002-09-6
5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide

Guidance literature:: With dmap; In N,N-dimethyl-formamide;

Reference yield:

: 2905-82-0
methyl 5-methoxy-2-hydroxybenzoate

: 551002-09-6
5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: I₂; KOH / methanol

2: Pd(PPh₃)2Cl₂; CuI; HNEt₂ / dimethylformamide

3: pyridine hydrochloride / 200 °C

4: EDCI / dimethylformamide

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; iodine; pyridine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; In methanol; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.bmcl.2004.07.029

Reference yield:

: 551002-38-1
methyl 3-iodo-5-methoxysalicylate

: 551002-09-6
5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carboxylic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: Pd(PPh₃)2Cl₂; CuI; HNEt₂ / dimethylformamide

2: pyridine hydrochloride / 200 °C

3: EDCI / dimethylformamide

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; pyridine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; In N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2004.07.029