6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide

Base Information

Chemical Name:6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide
CAS No.:1159603-87-8
Molecular Formula:C₁₉H₁₈ClN₃O₄
Molecular Weight:387.823
Hs Code.:

Synonyms:6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide

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Chemical Property of 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide

Chemical Property:

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Technology Process of 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide

There total 8 articles about 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1159603-85-6
6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid

: 156-87-6
propan-1-ol-3-amine

: 1159603-87-8
6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 1159603-80-1
6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

: 1159603-87-8
6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0 - 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water;

Reference yield:

: 3848-36-0
4-chlorobenzaldoxime

: 1159603-87-8
6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 - 35 °C

2.1: triethylamine / diethyl ether / 14 h / 20 °C

3.1: sodium hydroxide / ethanol; water / 20 °C

4.1: triethylamine / tetrahydrofuran / -10 - -5 °C

4.2: -10 - 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0 - 20 °C

With N-chloro-succinimide; lithium hydroxide monohydrate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; mineral oil;