Technology Process of C22H18N2O6
There total 5 articles about C22H18N2O6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid;
With
triethylamine; isobutyl chloroformate;
In
tetrahydrofuran;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
tetrahydrofuran; water;
at 20 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1021/jm401670x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
3.1: potassium carbonate; dihydrogen peroxide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
4.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere
5.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere
5.2: 1.5 h / 20 °C / Inert atmosphere
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); dihydrogen peroxide; potassium carbonate; potassium hydrogencarbonate; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
4.1: |Suzuki Coupling;
DOI:10.1021/jm401670x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
2.1: potassium carbonate; dihydrogen peroxide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere
4.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere
4.2: 1.5 h / 20 °C / Inert atmosphere
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); dihydrogen peroxide; potassium carbonate; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
3.1: |Suzuki Coupling;
DOI:10.1021/jm401670x
