(R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide

Base Information

• Chemical Name: (R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide
• CAS No.: 263553-51-1
• Molecular Formula: C₁₆H₁₇NO₃S
• Molecular Weight: 303.382
• Mol file: 263553-51-1.mol

Synonyms:(R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide

Chemical Property of (R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide

There total 3 articles about (R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(R)-N-methoxy-N-methyl-2-(toluene-4-sulfonylamino)-propionamide (1019853-12-3) + phenylmagnesium bromide (100-58-3) → (R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (263553-51-1)

Guidance literature:

(R)-N-methoxy-N-methyl-2-(toluene-4-sulfonylamino)-propionamide; phenylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 22h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/ol800318h

Reference yield:

N-chloro-4-methylbenzenesulfonamide (144-86-5) + (E)-tert-butyldimethyl(1-phenylprop-1-enyloxy)silane → (R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (263553-51-1) + (S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (206759-70-8)

Guidance literature:

With osmium(VIII) oxide; dihydroquinine-pyridazine ligand; In water; toluene; tert-butyl alcohol; at 25 ℃; for 0.25h; Title compound not separated from byproducts;

Reference yield:

chloroamine-T (127-65-1) + trimethyl[(Z)-(1-phenyl-1-propenyl)oxy]silane (66323-99-7) → (R)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (263553-51-1) + (S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (206759-70-8)

Guidance literature:

With PYRIMIDINE; osmium(VIII) oxide; dihydroquinidine; In water; toluene; tert-butyl alcohol; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(98)00035-4

upstream raw materials:

chloroamine-T

trimethyl[(Z)-(1-phenyl-1-propenyl)oxy]silane

N-chloro-4-methylbenzenesulfonamide

(R)-N-methoxy-N-methyl-2-(toluene-4-sulfonylamino)-propionamide

Downstream raw materials:

1(S),2(R),5(R)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane