N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Base Information

Chemical Name:N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt
CAS No.:1365990-71-1
Molecular Formula:C₁₆H₉ClF₂N₆S*ClH
Molecular Weight:427.264
Hs Code.:

Synonyms:N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

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Chemical Property of N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

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Technology Process of N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

There total 13 articles about N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1366230-90-1
N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine

: 1365990-71-1
N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 18h;

Reference yield:

: 79455-63-3
2-chloro-6-fluorobenzoyl chloride

: 1365990-71-1
N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: Multi-step reaction with 11 steps

1.1: pyridine / 3.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: thionyl chloride / 18 h / 100 °C

3.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 150 °C

3.2: 18 h / 150 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 19 h / 5 - 20 °C

5.1: trichlorophosphate / 0.75 h / 110 °C

6.1: trimethylsilyl bromide / propiononitrile / 72 h / 20 - 85 °C / Inert atmosphere

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 70 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 3 h / 50 °C

9.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 25 h / 70 - 80 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

11.1: hydrogenchloride / isopropyl alcohol / 18 h / 20 °C

With pyridine; hydrogenchloride; potassium phosphate; thionyl chloride; trimethylsilyl bromide; caesium carbonate; thiourea; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile;

Reference yield:

: 159783-22-9
3,5-difluoropyridin-4-ylamine

: 1365990-71-1
N-[2-(2-chloro-6-fluorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: Multi-step reaction with 11 steps

1.1: pyridine / 3.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: thionyl chloride / 18 h / 100 °C

3.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / 150 °C

3.2: 18 h / 150 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 19 h / 5 - 20 °C

5.1: trichlorophosphate / 0.75 h / 110 °C

6.1: trimethylsilyl bromide / propiononitrile / 72 h / 20 - 85 °C / Inert atmosphere

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 70 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 3 h / 50 °C

9.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 25 h / 70 - 80 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

11.1: hydrogenchloride / isopropyl alcohol / 18 h / 20 °C

With pyridine; hydrogenchloride; potassium phosphate; thionyl chloride; trimethylsilyl bromide; caesium carbonate; thiourea; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile;