2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Base Information

Chemical Name:2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide
CAS No.:1616851-89-8
Molecular Formula:C₃₀H₄₀ClN₃O₄
Molecular Weight:542.118
Hs Code.:

Synonyms:2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

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Chemical Property of 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

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Technology Process of 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

There total 15 articles about 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 478613-43-3
3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl methanesulfonate

: N-methyl-2-(3-methyl-2-oxo-1-(piperidin-4-yl)indolin-3-yl)acetamide hydrochloride salt

: 1616851-89-8
2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃;

Reference yield:

: 30096-07-2
methyl α-methyl-2-nitrobenzeneacetate

: 1616851-89-8
2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

2.1: acetic acid / methanol / 1 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h / 20 °C

4.1: ethanol / 80 °C / Sealed tube

5.1: hydrogenchloride / methanol / 1 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

With hydrogenchloride; ethanol; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3740-52-1
2-(2-nitrophenyl)acetic acid

: 1616851-89-8
2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 0.5 h / 20 - 60 °C

2.1: dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 20 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

4.1: acetic acid / methanol / 1 h / Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 1 h / 20 °C

6.1: ethanol / 80 °C / Sealed tube

7.1: hydrogenchloride / methanol / 1 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

With hydrogenchloride; thionyl chloride; ethanol; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;