2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1032358-19-2
• Molecular Formula: C₂₁H₃₅BO₃
• Molecular Weight: 346.318
• Mol file: 1032358-19-2.mol

Synonyms:2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 1 articles about 2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) + 4-methoxy-3,5-di-tert-butylphenylboronic acid pinacol ester (233584-42-4) → 2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1032358-19-2)

Guidance literature:

In tetrahydrofuran; Molecular sieve;

DOI:10.1002/ejoc.200701023

Reference yield: 85.0%

4-bromopyridine-1-oxide (14248-50-1) + 2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1032358-19-2) → 4-(3,5-di-tert-butyl-4-methoxyphenyl)pyridine-1-oxide (1032358-33-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; for 72h; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.200701023

Reference yield: 85.0%

4-bromo-3,5-diethylpyridine-1-oxide (1032358-29-4) + 2-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1032358-19-2) → 4-(3,5-di-tert-butyl-4-methoxyphenyl)-3,5-diethylpyridine-1-oxide (1032358-40-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; for 168h; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.200701023

upstream raw materials:

2,3-dimethyl-2,3-butane diol

4-methoxy-3,5-di-tert-butylphenylboronic acid pinacol ester

Downstream raw materials:

4-(3,5-di-tert-butyl-4-methoxyphenyl)pyridine-1-oxide

4-(3,5-di-tert-butyl-4-methoxyphenyl)-3-methylpyridine-1-oxide

4-(3,5-di-tert-butyl-4-methoxyphenyl)-3,5-diethylpyridine-1-oxide

4-(3,5-di-tert-butyl-4-methoxyphenyl)-3,5-diisopropylpyridine-1-oxide