4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide

Base Information

• Chemical Name: 4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide
• CAS No.: 92740-67-5
• Molecular Formula: C₂₆H₂₈N₄O₄S₂*HI
• Molecular Weight: 652.577
• Mol file: 92740-67-5.mol

Synonyms:4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide

Chemical Property of 4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide

There total 8 articles about 4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-Phenyl-3-(4-thiocarbamoyl-phenyl)-2-[2-(toluene-4-sulfonylamino)-acetylamino]-propionamide (92771-14-7) + methyl iodide (74-88-4) → 4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide (92740-67-5)

Guidance literature:

In acetone; for 48h; Ambient temperature;

Reference yield:

N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester (52117-01-8) → 4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide (92740-67-5)

Guidance literature:

Multi-step reaction with 6 steps

1: NaOH (1 mol/l) / acetic acid; H₂O / pH 3.8-4.0

2: NaOH (1 mol/l) / diethyl ether; ethyl acetate; H₂O / 10 h

3: 60 percent / DCC / pyridine / 12 h / Ambient temperature

4: 73 percent / pyridine / 2 h / 60 °C

5: 85 percent / H₂S, TEA / pyridine / 72 h / Ambient temperature

6: 84 percent / acetone / 48 h / Ambient temperature

With sodium hydroxide; TEA; hydrogen sulfide; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; water; acetic acid; ethyl acetate; acetone;

Reference yield:

2-(4-methylphenylsulfonamido)acetyl chloride (56218-62-3) → 4-{2-Phenylcarbamoyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide (92740-67-5)

Guidance literature:

Multi-step reaction with 5 steps

1: NaOH (1 mol/l) / diethyl ether; ethyl acetate; H₂O / 10 h

2: 60 percent / DCC / pyridine / 12 h / Ambient temperature

3: 73 percent / pyridine / 2 h / 60 °C

4: 85 percent / H₂S, TEA / pyridine / 72 h / Ambient temperature

5: 84 percent / acetone / 48 h / Ambient temperature

With sodium hydroxide; TEA; hydrogen sulfide; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; water; ethyl acetate; acetone;

upstream raw materials:

N-Phenyl-3-(4-thiocarbamoyl-phenyl)-2-[2-(toluene-4-sulfonylamino)-acetylamino]-propionamide

methyl iodide

N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester

2-(4-methylphenylsulfonamido)acetyl chloride

Downstream raw materials:

3-(4-Carbamimidoyl-phenyl)-N-phenyl-2-[2-(toluene-4-sulfonylamino)-acetylamino]-propionamide; hydrochloride