N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
CAS No.:1386980-59-1
Molecular Formula:C₂₆H₂₅ClN₆O₄
Molecular Weight:520.975
Hs Code.:

Synonyms:N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

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Technology Process of N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

There total 10 articles about N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

: 1386982-08-6
tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

: 1386980-59-1
N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

With sodium carbonate; In dichloromethane;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1386980-59-1
N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.67 h / -78 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 18 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 116437-41-3
tert-butyl (4-oxo-4-phenyl-butyl)-carbamate

: 1386980-59-1
N-(5-(4-Amino-1-phenylbutylcarbamoyl)-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;