tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

Base Information

Chemical Name:tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate
CAS No.:1386982-08-6
Molecular Formula:C₃₁H₃₃ClN₆O₆
Molecular Weight:621.093
Hs Code.:

Synonyms:tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

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Chemical Property of tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

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Technology Process of tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

There total 8 articles about tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

: 357443-58-4
(4-Amino-4-phenylbutyl)carbamic acid, 1,1-dimethylethyl ester

: 1386980-75-1
4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid

: 1386982-08-6
tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

Guidance literature:: 4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(4-Amino-4-phenylbutyl)carbamic acid, 1,1-dimethylethyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1386982-08-6
tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.67 h / -78 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 18 h / 20 °C

With hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: (E)-tert-butyl 4-(hydroxyimino)-4-phenylbutylcarbamate

: 1386982-08-6
tert-butyl 4-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-4-phenylbutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 18 h / 20 °C

With hydrogen; triethylamine; HATU; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;