{2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane

Base Information

Chemical Name:{2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane
CAS No.:919608-21-2
Molecular Formula:C₄₇H₆₆O₅Si
Molecular Weight:739.124
Hs Code.:

{2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-<i>tert</i>-butyl-diphenyl-silane

Synonyms:{2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane

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Chemical Property of {2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane

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Technology Process of {2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane

There total 25 articles about {2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 919608-20-1
5-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-furan-2-carbaldehyde

: (2-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-propyl)-triphenyl-phosphonium; iodide

: 919608-21-2
{2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane

Guidance literature:: (2-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-propyl)-triphenyl-phosphonium; iodide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

5-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-furan-2-carbaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1002/anie.200602860

Reference yield:

: 919608-13-2
{5-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-furan-2-yl}-methanol

: 919608-21-2
{2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / SO₃*pyridine; TEA; DMSO / CH₂Cl₂ / 0.5 h / 20 °C

2: 557 mg / tetrahydrofuran; hexane / -78 - 20 °C

With pyridine-SO₃ complex; TEA; dimethyl sulfoxide; In tetrahydrofuran; hexane; dichloromethane; 2: Wittig olefination;
DOI:10.1016/j.tet.2007.07.005

Reference yield:

: 919608-28-9
3-[5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 919608-21-2
{2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-but-1-enyl)-tetrahydro-furan-2-yl]-propoxy}-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C

2: 3.59 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

3: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

4: 84 percent / CSA; methanol / 2 h / 20 °C

5: 80 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

6: 89 percent / SO₃*pyridine; TEA; DMSO / CH₂Cl₂ / 0.5 h / 20 °C

7: 557 mg / tetrahydrofuran; hexane / -78 - 20 °C

With 1H-imidazole; methanol; lithium borohydride; pyridine-SO₃ complex; TEA; camphor-10-sulfonic acid; sodium hexamethyldisilazane; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 5: Williamson ether synthesis / 7: Wittig olefination;
DOI:10.1016/j.tet.2007.07.005