2-(2-Methylphenyl)aniline

Base Information

• Chemical Name: 2-(2-Methylphenyl)aniline
• CAS No.: 1203-41-4
• Molecular Formula: C13H13N
• Molecular Weight: 183.253
• Hs Code.: 29214990
• European Community (EC) Number: 673-282-1
• Nikkaji Number: J36.163A
• ChEMBL ID: CHEMBL1722879
• Mol file: 1203-41-4.mol

Synonyms:1203-41-4;2-(2-methylphenyl)aniline;2'-methyl[1,1'-biphenyl]-2-amine;2'-Methyl-[1,1'-biphenyl]-2-amine;2'-methylbiphenyl-2-amine;2/'-METHYL-BIPHENYL-2-YLAMINE;2'-Methyl[1,1'-biphenyl]-2-amine, HCl;2'-METHYL-BIPHENYL-2-YLAMINE;o-Tolylanilin;2-amino-2'-methyl-biphenyl;Oprea1_851147;MLS000702387;SCHEMBL398724;CHEMBL1722879;JISVTVYXQCPMEN-UHFFFAOYSA-N;HMS2604A12;BAA20341;STK523142;AKOS002683530;(2'-METHYLBIPHENYL-2-YL)AMINE;AS-59634;SMR000226370;BB 0222436;CS-0313082;FT-0722448

Chemical Property of 2-(2-Methylphenyl)aniline

Chemical Property:

• Boiling Point: 302.4 °C at 760 mmHg
• Flash Point: 143.6 °C
• PSA: 26.02000
• LogP: 3.82540
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 183.104799419
• Heavy Atom Count: 14
• Complexity: 178

Purity/Quality:

98%,99%, ^*data from raw suppliers

2''-Methyl[1,1''-biphenyl]-2-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C2=CC=CC=C2N

Technology Process of 2-(2-Methylphenyl)aniline

There total 20 articles about 2-(2-Methylphenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Methylphenylboronic acid (16419-60-6) + 2-bromoaniline (615-36-1) → 2-(2-methylphenyl)aniline (1203-41-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; Inert atmosphere;

DOI:10.1002/chem.201200888

Reference yield: 89.0%

2-Methylphenylboronic acid (16419-60-6) + o-chloroaniline (95-51-2) → 2-(2-methylphenyl)aniline (1203-41-4)

Guidance literature:

With C₂₈H₄₄N₂PPd; potassium carbonate; In ethanol; water; at 50 ℃; for 4h;

DOI:10.1021/ol102677r

Reference yield: 84.0%

2-iodophenylamine (615-43-0) + 2-Methylphenylboronic acid (16419-60-6) → 2-(2-methylphenyl)aniline (1203-41-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1039/c7gc02261a

upstream raw materials:

2-methyl-2'-nitro-1,1'-biphenyl

ortho-methylphenyl iodide

ortho-nitrobenzoic acid

N-chloro-N-methyl-4-toluene sulphonamide

Downstream raw materials:

2-iodo-2’-methylbiphenyl

2'-methyl-biphenyl-2-sulfonyl chloride

1-[2-(2-methylphenyl)phenyl]piperazine hydrochloride

phenanthridine