(S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 726192-95-6
• Molecular Formula: C₁₉H₃₀N₂O₄S
• Molecular Weight: 382.524

Synonyms:(S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property of (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

There total 5 articles about (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) + Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester (726192-09-2) → (S)-4-[(R)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester + (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (726192-95-6)

Guidance literature:

With thymidine 5'-phosphate; In acetonitrile; Heating;

DOI:10.1021/jm0155401

Reference yield:

N-(t-butoxycarbonyloxy)-phthalimide (15263-20-4) → (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (726192-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: TMP / acetonitrile / Heating

With thymidine 5'-phosphate; In acetonitrile;

DOI:10.1021/jm0155401

Reference yield:

4-(methanesulfonyl)acetophenone (10297-73-1) → (S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (726192-95-6)

Guidance literature:

Multi-step reaction with 3 steps

1: BH₃*SMe₂; chiral deriv. of oxazaboralodinone

2: Et₃N

3: TMP / acetonitrile / Heating

With dimethylsulfide borane complex; chiral deriv. of oxazaboralodinone; thymidine 5'-phosphate; triethylamine; In acetonitrile;

DOI:10.1021/jm0155401

upstream raw materials:

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Methanesulfonic acid (R)-1-(4-methanesulfonyl-phenyl)-ethyl ester

N-(t-butoxycarbonyloxy)-phthalimide

4-(methanesulfonyl)acetophenone

Downstream raw materials:

4-{(S)-4-[(S)-1-(4-Methanesulfonyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidine-1-carboxylic acid tert-butyl ester

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