6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril

Base Information

• Chemical Name: 6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril
• CAS No.: 78346-32-4
• Molecular Formula: C₂₃H₃₁N₃O₃
• Molecular Weight: 397.517
• Mol file: 78346-32-4.mol

Synonyms:6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril

Chemical Property of 6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril

There total 4 articles about 6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylpiperazine (17766-28-8) + methanol (67-56-1) + 4-(2-oxo-1,2-dihydro-quinolin-6-yloxy)-butyric acid (58899-33-5) + isobutyl chloroformate (543-27-1) → 6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril (78346-32-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In chloroform;

Reference yield:

6-hydroxy-1H-quinolin-2-one (19315-93-6) → 6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril (78346-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / 1,8-diazabicyclo<5,4,0>undec-7-ene (DBU) / propan-2-ol / 4 h / Heating

2: 95 percent / 20percent HCl / 2 h / 85 - 90 °C

3: 1.) isobutyl chloroformate, 1,8-diazabicyclo<5,4,0>undec-7-ene (DBU) / 1.) CHCl₃, r.t., 1 h, 2.) CHCl₃, r.t., 3 h

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; isobutyl chloroformate; In isopropyl alcohol;

DOI:10.1248/cpb.31.852

Reference yield:

methyl 4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyrate (87364-41-8) → 6-[3-(4-Cyclohexyl-1-piperazinylcarbonyl)propoxy]carbostyril (78346-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 20percent HCl / 2 h / 85 - 90 °C

2: 1.) isobutyl chloroformate, 1,8-diazabicyclo<5,4,0>undec-7-ene (DBU) / 1.) CHCl₃, r.t., 1 h, 2.) CHCl₃, r.t., 3 h

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; isobutyl chloroformate;

DOI:10.1248/cpb.31.852

upstream raw materials:

cyclohexylpiperazine

4-(2-oxo-1,2-dihydro-quinolin-6-yloxy)-butyric acid

6-hydroxy-1H-quinolin-2-one

methyl 4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyrate