C₂₇H₂₉F₆N₇O₂

Base Information

• Chemical Name: C₂₇H₂₉F₆N₇O₂
• CAS No.: 936482-53-0
• Molecular Formula: C₂₇H₂₉F₆N₇O₂
• Molecular Weight: 597.563
• Mol file: 936482-53-0.mol

Synonyms:C₂₇H₂₉F₆N₇O₂

Chemical Property of C₂₇H₂₉F₆N₇O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₉F₆N₇O₂

There total 6 articles about C₂₇H₂₉F₆N₇O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H15F3N2O3 → C27H29F6N7O2 (936482-53-0)

Guidance literature:

Multi-step reaction with 6 steps

1: borane dimethylsulfide complex / tetrahydrofuran / 70 °C

2: Zn; AcOH / ethanol / 75 °C

3: 3.68 g / tetrahydrofuran; CH₂Cl₂

4: 96 percent / ammonium formate; MeOH / Pd/C / 1.5 h / Heating

5: 86 percent / i-PrNEt₂ / propan-2-ol / 1.3 h / 100 °C

6: TEA / propan-2-ol / 0.42 h / 150 °C / microwave irradiation

With methanol; N,N-diethyl-N-isopropylamine; dimethylsulfide borane complex; TEA; ammonium formate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm061436d

Reference yield:

C18H17F3N2O2 → C27H29F6N7O2 (936482-53-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Zn; AcOH / ethanol / 75 °C

2: 3.68 g / tetrahydrofuran; CH₂Cl₂

3: 96 percent / ammonium formate; MeOH / Pd/C / 1.5 h / Heating

4: 86 percent / i-PrNEt₂ / propan-2-ol / 1.3 h / 100 °C

5: TEA / propan-2-ol / 0.42 h / 150 °C / microwave irradiation

With methanol; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm061436d

Reference yield:

C18H19F3N2 → C27H29F6N7O2 (936482-53-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 3.68 g / tetrahydrofuran; CH₂Cl₂

2: 96 percent / ammonium formate; MeOH / Pd/C / 1.5 h / Heating

3: 86 percent / i-PrNEt₂ / propan-2-ol / 1.3 h / 100 °C

4: TEA / propan-2-ol / 0.42 h / 150 °C / microwave irradiation

With methanol; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm061436d

upstream raw materials:

2-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,2-a]pyrazine

tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

tert-butyl (3R,4R)-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Refernces