Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate

Base Information

• Chemical Name: Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate
• CAS No.: 55899-30-4
• Molecular Formula: C₁₀H₉BrN₂O₂
• Molecular Weight: 269.098
• DSSTox Substance ID: DTXSID00480505
• Nikkaji Number: J3.660.943E
• Wikidata: Q82315308
• Mol file: 55899-30-4.mol

Synonyms:Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate;55899-30-4;Ethyl6-bromopyrazolo[1,5-a]pyridine-3-carboxylate;SCHEMBL2288847;AMY7609;DTXSID00480505;JWXJCAUKPCUMLO-UHFFFAOYSA-N;MFCD17926419;AKOS016001567;PB30272;AS-37836;CS-0049419;A870066

Chemical Property of Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property:

• Melting Point: 119-120 °C(Solv: ligroine (8032-32-4))
• PKA: -0.46±0.30(Predicted)
• Density: 1.60±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 267.98474
• Heavy Atom Count: 15
• Complexity: 250

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C2C=CC(=CN2N=C1)Br

Technology Process of Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate

There total 10 articles about Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

3-bromo-N-aminopyridinium mesitylenesulphonate + propynoic acid ethyl ester (623-47-2) → ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate (55899-30-4)

Guidance literature:

3-bromo-N-aminopyridinium mesitylenesulphonate; With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

propynoic acid ethyl ester; In acetone; for 6h;

Reference yield: 29.0%

3-Bromopyridine (626-55-1,163928-56-1) + propynoic acid ethyl ester (623-47-2) → ethyl 4-bromopyrazolo[1,5-a]pyridine-3-carboxylate (55899-29-1) + ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate (55899-30-4)

Guidance literature:

3-Bromopyridine; With mesitylenesulfonylhydroxylamine; In dichloromethane; at 0 ℃; for 2h;

propynoic acid ethyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2011.11.029

Reference yield: 22.0%

1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzenesulfonate (55899-13-3) + propynoic acid ethyl ester (623-47-2) → ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate (55899-30-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Cooling with ice;

upstream raw materials:

propynoic acid ethyl ester

3-Bromopyridine

1-amino-3-bromopyridinium iodide

1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzenesulfonate

Downstream raw materials:

ethyl 6-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate

N'-((6-bromopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

6- bromopyrazolo[1,5-a]pyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 55899-30-4 ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send