5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine

Base Information

Chemical Name:5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine
CAS No.:1361187-57-6
Molecular Formula:C₂₄H₂₅N₉O
Molecular Weight:455.522
Hs Code.:

Synonyms:5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine

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Chemical Property of 5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine

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Technology Process of 5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine

There total 7 articles about 5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361190-35-3
5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

: 1361187-57-6
5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine

Guidance literature:: 5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester; With methanol; acetyl chloride; at 20 ℃;

With ammonia; In methanol;

Reference yield:

: 1361190-18-2
C₂₅H₂₉BrN₆O₃

: 1361187-57-6
5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 100 °C

2: acetyl chloride; methanol / 20 °C

With methanol; sodium carbonate; acetyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 1361190-23-9
C₃₁H₄₁BN₆O₅

: 1361187-57-6
5-(4-{1-[5-(3,4,5,6-tetrahydro-2H-1,2'-bipyrazinyl-5'-yl)-1,2,4-oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 85 °C / Microwave irradiation

2: acetyl chloride; methanol / 20 °C

With methanol; sodium carbonate; acetyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;