5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

Base Information

Chemical Name:5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester
CAS No.:1361190-35-3
Molecular Formula:C₂₉H₃₃N₉O₃
Molecular Weight:555.64
Hs Code.:

Synonyms:5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

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Chemical Property of 5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

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Technology Process of 5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

There total 6 articles about 5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

: 1361190-18-2
C₂₅H₂₉BrN₆O₃

: 1361190-35-3
5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield:

: 59489-71-3
5-amino-2-bromopyrazine

: 1361190-23-9
C₃₁H₄₁BN₆O₅

: 1361190-35-3
5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 85 ℃; for 16h; Microwave irradiation;

Reference yield:

: 1209646-17-2
5-(4-(tert-butoxycarbonyl)piperazin-1-yl) pyrazine-2-carboxylic acid

: 1361189-49-2
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxycyclobutanecarboxamidine

: 1361190-35-3
5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

Guidance literature:: 5-(4-(tert-butoxycarbonyl)piperazin-1-yl) pyrazine-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In 1,4-dioxane; at 50 ℃; for 0.5h;

1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxycyclobutanecarboxamidine; In 1,4-dioxane; at 80 ℃; for 18h;