2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Base Information

Chemical Name:2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide
CAS No.:368426-31-7
Molecular Formula:C₂₄H₂₉N₅O₆S
Molecular Weight:515.59
Hs Code.:

2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-<i>N</i>-[4-(<i>N</i>-hydroxycarbamimidoyl)-benzyl]-acetamide

Synonyms:2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

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Chemical Property of 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

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Technology Process of 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

There total 10 articles about 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 368426-31-7
2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / K₂CO₃ / tetrahydrofuran / 18 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / 35 °C

2.2: 97 percent / tetrahydrofuran / 15 h / 0 - 20 °C

3.1: 100 percent / 5 M HCl / ethyl acetate / 0 - 20 °C

4.1: 83 percent / Et₃N / acetonitrile / 0 - 20 °C

5.1: H₂ / Pd/C / methanol; toluene / 2327.17 Torr

6.1: NMM; BOP / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0960-894X(02)00010-0

Reference yield:

: 84466-87-5
4-(azidomethyl)benzonitrile

: 368426-31-7
2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / H₂ / Pd/C / ethyl acetate / 11 h / 2327.17 Torr

2: 89 percent / NH₂OH*HCl; NMM / methanol / 72 h / 20 °C

3: NMM; BOP / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydroxylamine hydrochloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00010-0

Reference yield:

: 76944-95-1
tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate

: 368426-31-7
2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiHMDS / tetrahydrofuran / 35 °C

1.2: 97 percent / tetrahydrofuran / 15 h / 0 - 20 °C

2.1: 100 percent / 5 M HCl / ethyl acetate / 0 - 20 °C

3.1: 83 percent / Et₃N / acetonitrile / 0 - 20 °C

4.1: H₂ / Pd/C / methanol; toluene / 2327.17 Torr

5.1: NMM; BOP / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0960-894X(02)00010-0