C₁₂H₇BrClN₃

Base Information

• Chemical Name: C₁₂H₇BrClN₃
• CAS No.: 1314787-70-6
• Molecular Formula: C₁₂H₇BrClN₃
• Molecular Weight: 308.565
• Mol file: 1314787-70-6.mol

Synonyms:C₁₂H₇BrClN₃

Chemical Property of C₁₂H₇BrClN₃

Chemical Property:

Purity/Quality:

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Technology Process of C₁₂H₇BrClN₃

There total 1 articles about C₁₂H₇BrClN₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

C12H9ClN4 (1314787-69-3) → C12H7BrClN3 (1314787-70-6)

Guidance literature:

C₁₂H₉ClN₄; With sulfuric acid; sodium nitrite; In acetic acid; at 10 - 20 ℃; for 0.5h;

With hydrogen bromide; copper(I) bromide; In sulfuric acid; water; acetic acid; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 39.0%

3-methoxy-4-(2-methylpyridin-4-yl)aniline (1161361-88-1) + C12H7BrClN3 (1314787-70-6) → 8-(2-chlorophenyl)-N-[3-methoxy-4-(2-methyl-4-pyridinyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine (1314786-38-3)

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 110 ℃; for 20h; Inert atmosphere;

Reference yield: 5.0%

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (958245-18-6) + carbon monoxide (201230-82-2) + C12H7BrClN3 (1314787-70-6) → 8-(2-chlorophenyl)-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine-2-carboxamide

Guidance literature:

With triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 110 ℃; for 18h; under 15001.5 Torr; Autoclave;

upstream raw materials:

C₁₂H₉ClN₄

Downstream raw materials:

8-(2-chlorophenyl)-N-[3-methoxy-4-(2-methyl-4-pyridinyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine