6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

Base Information

Chemical Name:6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide
CAS No.:1072711-03-5
Molecular Formula:C₂₇H₂₀F₃N₅O₂
Molecular Weight:503.483
Hs Code.:

Synonyms:6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

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Chemical Property of 6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

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Technology Process of 6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

There total 7 articles about 6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072710-67-8
6-[[2-(acetylamino)-pyridin-4-yl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

: 1072711-03-5
6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

Guidance literature:: 6-[[2-(acetylamino)-pyridin-4-yl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide; With hydrogenchloride; water; In ethanol; at 100 ℃; for 5h;

With sodium hydroxide; water; In ethanol;

Reference yield:

: 1072710-68-9
6-(2-chloropyridin-4-yloxy)-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

: 1072711-03-5
6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C

2: hydrogenchloride; water / ethanol / 5 h / 100 °C

With hydrogenchloride; water; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol;

Reference yield:

: 1072710-70-3
6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide

: 1072711-03-5
6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 1 h / 55 °C

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C

4: hydrogenchloride; water / ethanol / 5 h / 100 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; water; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide;