6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Base Information

Chemical Name:6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide
CAS No.:1072711-04-6
Molecular Formula:C₃₁H₂₂F₃N₇O₃
Molecular Weight:597.556
Hs Code.:

6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Synonyms:6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Suppliers and Price of 6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

There total 7 articles about 6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16042-25-4
1H-imidazole-2-carboxylic acid

: 1072711-03-5
6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide

: 1072711-04-6
6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Guidance literature:: 1H-imidazole-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

6-[(6-amino-pyridin-4-yl)oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide; In N,N-dimethyl-formamide; at 60 ℃; for 21h;

Reference yield:

: 1072710-69-0
6-hydroxy-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide

: 1072711-04-6
6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 1 h / 55 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C

3.1: hydrogenchloride; water / ethanol / 5 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

4.2: 21 h / 60 °C

With hydrogenchloride; water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1072710-68-9
6-(2-chloropyridin-4-yloxy)-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

: 1072711-04-6
6-[[2-[(1H-imidazol-2-yl)carbonyl]amino-4-pyridinyl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C

2.1: hydrogenchloride; water / ethanol / 5 h / 100 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 21 h / 60 °C

With hydrogenchloride; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;