2-Methoxy-4-methyl-3-nitropyridine

Base Information

• Chemical Name: 2-Methoxy-4-methyl-3-nitropyridine
• CAS No.: 160590-36-3
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Hs Code.: 2933399090
• European Community (EC) Number: 674-934-8
• DSSTox Substance ID: DTXSID20450785
• Wikidata: Q72517279
• Mol file: 160590-36-3.mol

Synonyms:160590-36-3;2-methoxy-4-methyl-3-nitropyridine;2-Methoxy-3-nitro-4-methylpyridine;2-methoxy-3-nitro-4-picoline;Pyridine, 2-methoxy-4-methyl-3-nitro-;MFCD08277286;SCHEMBL7222277;DTXSID20450785;BGHDKUHZYJCOQG-UHFFFAOYSA-N;4-methyl-2-methoxy-3-nitropyridine;AC1622;2-methoxy-3-nitro-4-methyl pyridine;AKOS006346045;PB48906;DS-11324;SY023709;A3552;CS-0082356;FT-0645872;J-509793

Chemical Property of 2-Methoxy-4-methyl-3-nitropyridine

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Melting Point: 38-40 °C
• Refractive Index: 1.542
• Boiling Point: 270.28 °C at 760 mmHg
• PKA: 0.02±0.18(Predicted)
• Flash Point: 117.261 °C
• PSA: 67.94000
• Density: 1.248 g/cm³
• LogP: 1.83000
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 168.05349212
• Heavy Atom Count: 12
• Complexity: 169

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-3-nitro-4-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)OC)[N+](=O)[O-]

Technology Process of 2-Methoxy-4-methyl-3-nitropyridine

There total 3 articles about 2-Methoxy-4-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-3-nitro-4-methylpyridine (23056-39-5) + sodium methylate (124-41-4) → 2-methoxy-4-methyl-3-nitropyridine (160590-36-3)

Guidance literature:

In methanol; at 0 ℃; for 25h; Reflux;

Reference yield: 100.0%

methanol (67-56-1) + 2-chloro-3-nitro-4-methylpyridine (23056-39-5) + sodium methylate (124-41-4) → 2-methoxy-4-methyl-3-nitropyridine (160590-36-3)

Guidance literature:

at 0 ℃; for 25h; Reflux;

DOI:10.1021/acs.jmedchem.6b00264

Reference yield: 48.0%

methanol (67-56-1) + 2-chloro-3-nitro-4-methylpyridine (23056-39-5) → 2-methoxy-4-methyl-3-nitropyridine (160590-36-3)

Guidance literature:

With potassium tert-butylate; at 0 ℃; for 12h; Reflux;

upstream raw materials:

2-chloro-3-nitro-4-methylpyridine

sodium methylate

methanol

Downstream raw materials:

3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (2-methoxy-4-methyl-pyridin-3-yl)-amide