Technology Process of 2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-9-(6-pyrrolidin-1-yl-pyridin-3-yl)-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene
There total 12 articles about 2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-9-(6-pyrrolidin-1-yl-pyridin-3-yl)-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
1-methyl-pyrrolidin-2-one;
at 150 ℃;
for 2h;
Sealed tube;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: -78 °C
2.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C
3.1: toluene / 2 h / 90 °C
3.2: 2 h / 90 °C
4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube
5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation
6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation
With
n-butyllithium; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube
2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation
3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation
With
caesium carbonate; N-ethyl-N,N-diisopropylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1-methyl-pyrrolidin-2-one; water; acetonitrile;
1: Suzuki Coupling;