Technology Process of 2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-9-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene
There total 11 articles about 2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-9-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
1-methyl-pyrrolidin-2-one;
at 150 ℃;
for 2h;
Inert atmosphere;
Sealed tube;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C
3.1: potassium carbonate; tetraethylammonium chloride / triphenylphosphine; palladium diacetate / acetonitrile / 3 h / 80 °C / Inert atmosphere
4.1: N-Bromosuccinimide; acetic acid / dichloromethane / 0 - 5 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
5.2: -78 °C
6.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C
7.1: toluene / 2 h / 90 °C
7.2: 2 h / 90 °C
8.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube
9.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation
With
N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; tetraethylammonium chloride; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
8.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube
2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation
With
caesium carbonate; N-ethyl-N,N-diisopropylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1-methyl-pyrrolidin-2-one; water; acetonitrile;
1: Suzuki Coupling;