Technology Process of 2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-9-(6-fluoro-pyridin-3-yl)-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene
There total 10 articles about 2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-9-(6-fluoro-pyridin-3-yl)-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
water; acetonitrile;
at 80 ℃;
for 1h;
Inert atmosphere;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C
3.1: potassium carbonate; tetraethylammonium chloride / triphenylphosphine; palladium diacetate / acetonitrile / 3 h / 80 °C / Inert atmosphere
4.1: N-Bromosuccinimide; acetic acid / dichloromethane / 0 - 5 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
5.2: -78 °C
6.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C
7.1: toluene / 2 h / 90 °C
7.2: 2 h / 90 °C
8.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube
With
N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; tetraethylammonium chloride; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
8.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: iodine; sodium carbonate / water; tetrahydrofuran / 4 h / 20 °C
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C
3.1: potassium carbonate; tetraethylammonium chloride / triphenylphosphine; palladium diacetate / acetonitrile / 3 h / 80 °C / Inert atmosphere
4.1: N-Bromosuccinimide; acetic acid / dichloromethane / 0 - 5 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
5.2: -78 °C
6.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C
7.1: toluene / 2 h / 90 °C
7.2: 2 h / 90 °C
8.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube
With
N-Bromosuccinimide; n-butyllithium; di-isopropyl azodicarboxylate; tetraethylammonium chloride; iodine; sodium carbonate; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
8.1: Suzuki Coupling;