4-bromo-3-methyl-1-phenylsulphonylpyrazole

Base Information

• Chemical Name: 4-bromo-3-methyl-1-phenylsulphonylpyrazole
• CAS No.: 130874-31-6
• Molecular Formula: C₁₀H₉BrN₂O₂S
• Molecular Weight: 301.164
• Mol file: 130874-31-6.mol

Synonyms:4-bromo-3-methyl-1-phenylsulphonylpyrazole

Chemical Property of 4-bromo-3-methyl-1-phenylsulphonylpyrazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-bromo-3-methyl-1-phenylsulphonylpyrazole

There total 3 articles about 4-bromo-3-methyl-1-phenylsulphonylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-bromo-3-methyl-1H-pyrazole (13808-64-5) + benzenesulfonyl chloride (98-09-9) → 4-bromo-3-methyl-1-phenylsulphonylpyrazole (130874-31-6)

Guidance literature:

With pyridine; for 2h; Heating;

Reference yield:

benzenesulfonyl chloride (98-09-9) → 4-bromo-3-methyl-1-phenylsulphonylpyrazole (130874-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / pyridine / 2 h / Heating

2: 1) 2 M phenyl-lithium / 1) benzene, diethyl ether, -78 deg C to 0 deg C, 2 h, 2) diethyl ether, -78 deg C to rt, 14 h

With pyridine; phenyllithium;

Reference yield:

4-bromo-1-phenylsulphonylpyrazole (121358-73-4) + methyl iodide (74-88-4) → 4-bromo-3-methyl-1-phenylsulphonylpyrazole (130874-31-6)

Guidance literature:

With phenyllithium; Yield given. Multistep reaction; 1) benzene, diethyl ether, -78 deg C to 0 deg C, 2 h, 2) diethyl ether, -78 deg C to rt, 14 h;

upstream raw materials:

4-bromo-3-methyl-1H-pyrazole

benzenesulfonyl chloride

4-bromo-1-phenylsulphonylpyrazole

methyl iodide

Downstream raw materials:

4-bromo-3-methyl-1H-pyrazole